Use the DataFrame.select method:

In [38]: df = DataFrame({'Test1': randn(10), 'Test2': randn(10), 'awesome': randn(10)})

In [39]: df.select(lambda x: not re.search('Testd+', x), axis=1)
Out[39]:
   awesome
0    1.215
1    1.247
2    0.142
3    0.169
4    0.137
5   -0.971
6    0.736
7    0.214
8    0.111
9   -0.214

You can filter out the columns you DO want using ‘filter’

import pandas as pd
import numpy as np

data2 = [{'test2': 1, 'result1': 2}, {'test': 5, 'result34': 10, 'c': 20}]

df = pd.DataFrame(data2)

df

    c   result1     result34    test    test2
0   NaN     2.0     NaN     NaN     1.0
1   20.0    NaN     10.0    5.0     NaN

Now filter

df.filter(like='result',axis=1)

Get..

   result1  result34
0   2.0     NaN
1   NaN     10.0

Here is one way to do this:

df = df[df.columns.drop(list(df.filter(regex='Test')))]

This can be done neatly in one line with:

df = df.drop(df.filter(regex='Test').columns, axis=1)

Cheaper, Faster, and Idiomatic: str.contains

In recent versions of pandas, you can use string methods on the index and columns. Here, str.startswith seems like a good fit.

To remove all columns starting with a given substring:

df.columns.str.startswith('Test')
# array([ True, False, False, False])

df.loc[:,~df.columns.str.startswith('Test')]

  toto test2 riri
0    x     x    x
1    x     x    x

For case-insensitive matching, you can use regex-based matching with str.contains with an SOL anchor:

df.columns.str.contains('^test', case=False)
# array([ True, False,  True, False])

df.loc[:,~df.columns.str.contains('^test', case=False)] 

  toto riri
0    x    x
1    x    x

if mixed-types is a possibility, specify na=False as well.

This method does everything in place. Many of the other answers create copies and are not as efficient:

df.drop(df.columns[df.columns.str.contains('Test')], axis=1, inplace=True)

Using a regex to match all columns not containing the unwanted word:

df = df.filter(regex='^((?!badword).)*$')

You can use df.filter to get the list of columns that match your string and then use df.drop

resdf = df.drop(df.filter(like='Test',axis=1).columns.to_list(), axis=1)

Solution when dropping a list of column names containing regex. I prefer this approach because I’m frequently editing the drop list. Uses a negative filter regex for the drop list.

drop_column_names = ['A','B.+','C.*']
drop_columns_regex = '^(?!(?:'+'|'.join(drop_column_names)+')$)'
print('Dropping columns:',', '.join([c for c in df.columns if re.search(drop_columns_regex,c)]))
df = df.filter(regex=drop_columns_regex,axis=1)

Question states ‘I want to drop all the columns whose name contains the word "Test".’

test_columns = [col for col in df if 'Test' in col]
df.drop(columns=test_columns, inplace=True)