In Pandas version 0.13 and greater the index level names are immutable (type FrozenList) and can no longer be set directly. You must first use Index.rename() to apply the new index level names to the Index and then use DataFrame.reindex() to apply the new index to the DataFrame. Examples:

For Pandas version < 0.13

df.index.names = ['Date']

For Pandas version >= 0.13

df = df.reindex(df.index.rename(['Date']))

You can also use Index.set_names as follows:

In [25]: x = pd.DataFrame({'year':[1,1,1,1,2,2,2,2],
   ....:                   'country':['A','A','B','B','A','A','B','B'],
   ....:                   'prod':[1,2,1,2,1,2,1,2],
   ....:                   'val':[10,20,15,25,20,30,25,35]})

In [26]: x = x.set_index(['year','country','prod']).squeeze()

In [27]: x
Out[27]: 
year  country  prod
1     A        1       10
               2       20
      B        1       15
               2       25
2     A        1       20
               2       30
      B        1       25
               2       35
Name: val, dtype: int64
In [28]: x.index = x.index.set_names('foo', level=1)

In [29]: x
Out[29]: 
year  foo  prod
1     A    1       10
           2       20
      B    1       15
           2       25
2     A    1       20
           2       30
      B    1       25
           2       35
Name: val, dtype: int64

If you want to use the same mapping for renaming both columns and index you can do:

mapping = {0:'Date', 1:'SM'}
df.index.names = list(map(lambda name: mapping.get(name, name), df.index.names))
df.rename(columns=mapping, inplace=True)

For newer pandas versions

df.index = df.index.rename('new name')

or

df.index.rename('new name', inplace=True)

The latter is required if a data frame should retain all its properties.

The currently selected answer does not mention the rename_axis method which can be used to rename the index and column levels.

---

Pandas has some quirkiness when it comes to renaming the levels of the index. There is also a new DataFrame method rename_axis available to change the index level names.

Let’s take a look at a DataFrame

df = pd.DataFrame({'age':[30, 2, 12],
                       'color':['blue', 'green', 'red'],
                       'food':['Steak', 'Lamb', 'Mango'],
                       'height':[165, 70, 120],
                       'score':[4.6, 8.3, 9.0],
                       'state':['NY', 'TX', 'FL']},
                       index = ['Jane', 'Nick', 'Aaron'])

This DataFrame has one level for each of the row and column indexes. Both the row and column index have no name. Let’s change the row index level name to ‘names’.

df.rename_axis('names')

The rename_axis method also has the ability to change the column level names by changing the axis parameter:

df.rename_axis('names').rename_axis('attributes', axis='columns')

If you set the index with some of the columns, then the column name will become the new index level name. Let’s append to index levels to our original DataFrame:

df1 = df.set_index(['state', 'color'], append=True)
df1

Notice how the original index has no name. We can still use rename_axis but need to pass it a list the same length as the number of index levels.

df1.rename_axis(['names', None, 'Colors'])

You can use None to effectively delete the index level names.

---

Series work similarly but with some differences

Let’s create a Series with three index levels

s = df.set_index(['state', 'color'], append=True)['food']
s

       state  color
Jane   NY     blue     Steak
Nick   TX     green     Lamb
Aaron  FL     red      Mango
Name: food, dtype: object

We can use rename_axis similarly to how we did with DataFrames

s.rename_axis(['Names','States','Colors'])

Names  States  Colors
Jane   NY      blue      Steak
Nick   TX      green      Lamb
Aaron  FL      red       Mango
Name: food, dtype: object

Notice that the there is an extra piece of metadata below the Series called Name. When creating a Series from a DataFrame, this attribute is set to the column name.

We can pass a string name to the rename method to change it

s.rename('FOOOOOD')

       state  color
Jane   NY     blue     Steak
Nick   TX     green     Lamb
Aaron  FL     red      Mango
Name: FOOOOOD, dtype: object

DataFrames do not have this attribute and infact will raise an exception if used like this

df.rename('my dataframe')
TypeError: 'str' object is not callable

Prior to pandas 0.21, you could have used rename_axis to rename the values in the index and columns. It has been deprecated so don’t do this

df.index.rename('new name', inplace=True)

Is the only one that does the job for me (pandas 0.22.0).
Without the inplace=True, the name of the index is not set in my case.

you can use index and columns attributes of pandas.DataFrame. NOTE: number of elements of list must match the number of rows/columns.

#       A   B   C
# ONE   11  12  13
# TWO   21  22  23
# THREE 31  32  33

df.index = [1, 2, 3]
df.columns = ['a', 'b', 'c']
print(df)

#     a   b   c
# 1  11  12  13
# 2  21  22  23
# 3  31  32  33

For Single Index :

 df.index.rename('new_name')

For Multi Index :

 df.index.rename(['new_name','new_name2'])

WE can also use this in latest pandas :

rename_axis